what is the hygiene hypothesis and why is it the most important aspect of your health you’ve never heard of?


Hygiene Hypothesis

The pillar of all knowledge (Wikipedia) describes the Hygiene Hypothesis as, “a lack of early childhood exposure to infectious agents, symbiotic microorganisms (such as the gut flora or probiotics), and parasites, increases susceptibility to allergic diseases by suppressing the natural development of the immune system. In particular, the lack of exposure is thought to lead to defects in the establishment of immune tolerance.”  Great, but what does this really mean? 

Simple; if you are not being exposed to a wide array of germs and organisms (bacteria, viruses, molds, fungi, PARASITES, etc) from the time you are born, your chances of developing any number of diseases goes up significantly.  The kicker is that once you lose Immune Tolerance (OR FAIL TO ESTABLISH IT IN THE FIRST PLACE), your body begins seeing itself — its various organs, glands, cells, tissues, enzymes, etc — as foreign.  And once the body recognizes something as foreign, it begins attacking.  Can anyone say AUTOIMMUNITY?

Although people have been talking about this theory for centuries, the first person to actually coin the term ‘Hygiene Hypothesis‘ was one David Strachan, a Professor of Epidemiology at London’s St. George’s University.  His discoveries were published in a 1989 issue of the British Medical Journal (Hay Fever, Hygiene, and Household Size).  Interestingly enough, he began that study by saying, “Hay fever has been described as a post-industrial revolution epidemic“.  In other words, Hay Fever was not an issue as long as people largely lived agrarian lifestyles, with regular exposure to dirt, dust, manure, animals, etc, etc, and were not being exposed to the medications we’ll discuss in a moment.  He went on to say that, “infection in early childhood, transmitted by unhygienic contact with older siblings,” prevented said allergic diseases (Hay Fever) in the younger siblings.  Needless to say, in a society whose physicians basically promote cradle-to-grave germophobia, this idea went over like a proverbial lead balloon — at least initially.  But by Y2K momentum was shifting.

Quick history fact; the Berlin Wall came down in 1989.  In the early 1990’s, Dr Erika Von Mutius, a German pediatrician, ran a series of experiments comparing the rates of ASTHMA and ALLERGIES between East German children who typically grew up poor and dirty under the effects of COMMUNISM-INDUCED POVERTY, and West German children, who on average had about as high a standard of living as you’ll find anywhere in Europe.  She expected to see that cleanliness really is next to Godliness; at least as far as allergies and asthma were concerned.  Instead she saw the exact opposite.  The dirtier the children, the less likely they were to have A&A.  Today there are literally thousands upon thousands of similar studies — many having to do with autoimmune diseases (HERE’S ONE).  To see where Dr. Erika’s work has taken her over the past two decades, HERE is a cool study from last March’s issue of the Journal of Allergy and Clinical Immunology that sums up this topic.

Are there legitimate physicians and researchers who actually know their way around this subject, yet still deny the Hygiene Hypothesis exists?  Sure there are — kind of.  After reading last July’s Perspectives in Public Health (Time to Abandon the Hygiene Hypothesis: New Perspectives on Allergic Disease, the Human Microbiome, Infectious Disease Prevention and the Role of Targeted Hygiene), I began to see what the “deniers” looked like and were really after.  Despite having to admit that the premises of the Hygiene Hypothesis are real — “Evidence suggests a combination of strategies, including natural childbirth, breast feeding, increased social exposure through sport, other outdoor activities, less time spent indoors, diet and appropriate antibiotic use, may help restore the microbiome and perhaps reduce risks of allergic disease.” — the scientists went on to complain that what they hated most was that one of their medical words (hygiene) had been hijacked.  Thus, their demand that, “The term ‘hygiene hypothesis’ must be abandoned.”  I saw this same theme repeated in numerous articles and studies — never denying that the phenomenon is real, but detesting the language used to describe it.

Case in point; writing for PNAS back in February (News Feature: Cleaning up the Hygiene Hypothesis), Megan Scudellari made essentially the same appeal, which carried two distinct points.  The first is what I talked about in the last paragraph — that the term “Hygiene Hypothesis” does not really explain what’s going on because it’s too broad, covers too much territory, and alters the common medical meaning of the word “hygiene”.  The second had to do with the fact that even though the data does not lie (there is an inarguable relationship between hygiene — or the lack thereof — and a slew of health-related factors and diseases), the Hygiene Hypothesis cannot be true because there is no one-size-fits-all probiotic “cure”.

The second major concern among researchers is a lack of evidence demonstrating how to reduce rates of allergic and autoimmune diseases. Although there are hundreds of observational and epidemiological studies supporting a more nuanced theory that moves beyond the hygiene hypothesis, there are only a few randomized, controlled prospective studies testing interventions to reregulate the immune system. These include an experimental infection with helminths to treat IBD, which met with mixed results, and probiotics treatments for illnesses ranging from severe acute pancreatitis to eczema. In some cases, probiotics alleviated symptoms, but, in others, they had no effect.”

Scudellari’s mistake is that she is looking at this problem through the lens of other medical treatments. Your testosterone is low?  We’ll just give you some testosterone (HERE).  Not enough insulin to lower your blood sugar?  We have drugs that do the same thing (HERE).  Feeling a bit down because presumably your body is not making enough neurotransmitters (serrotonin / dopamine)?  We’ll start pumping the ANTIDEPRESSANTS. And of course all women need HRT

The problem is, not only does this short-sighted approach always fail over the long run, it suppresses your body’s natural negative feedback loops, frequently leaving you worse than when you started (when’s the last time insulin helped a TYPE II DIABETIC actually solve their problem?).  And here’s the rub; there are only about a jillion studies showing that all of these problems are INFLAMMATORY IN NATURE and intimately linked to one’s MICROBIOME (the numbers and ratios of the various strains of bacteria found in the Gut).   If that’s really the case, why can’t we just give everyone a probiotic?  It’s really quite easy to understand.

Scudallari is certainly right about one thing — studies on PROBIOTICS are all over the map (my friend Dr. Eric Serrano — an OB/GYN, past head of a major ICU, expert in FUNCTIONAL MEDICINE, and nutritional specialist for elite strength athletes — sometimes lectures on the potential side effects of probiotics).  For every study that “proves” a certain disease can be beneficially affected by taking a probiotic, another study seems to “prove” otherwise.  In other words, probiotics are the definition of a ‘mixed bag’.  Frankly, I’m not surprised, and you shouldn’t be either. 

Depending on whose research you look at, a normal human microbiome contains something like 300 to 600 strains of bacteria, give or take.  These bacteria must work in tandem with each other; like members of an orchestra.  All it takes is one member out of tune or rhythm for the music to start sounding “off”.  Get a few more members off key or out of rhythm and the whole thing starts devolving into chaos.

It’s why even though I do not do them in my clinic, I have a DOZEN OR SO ARTICLES on FMT (Fecal Microbiota Transplants); one of them explaining why taking generic probiotic formulas with 1, 2, 8, or even 15 strains of bacteria, is not going to be enough to reestablish and heal the microbiota of many people — especially really sick people (HERE).  But when the alternate to probiotics is DANGEROUS DRUGS, what have you got to lose?  Worst case scenario, it doesn’t work.  What are you out?  A couple bottles of probiotics?  Who cares!  And as for those weird studies showing amazing benefits for many people purposefully being infected with parasitic worms known as HELMINTHS, there isn’t “a study as in one, there are dozens of such studies; many of which show promising results for those with IBS or IBD that has not responded to anything else. 

Today, there are tens of thousands of studies concerning the HYGIENE HYPOTHESIS — many, if not most, having to do with the MICROBIOME (on Pubmed, search for Gut Flora, Microbiome, Microbiota, Hygiene Hypothesis, Autoimmunity, etc, etc).  The thing that’s so astounding is that you can name virtually any disease that’s NOT 100% GENETIC (something like Down’s or Cystic Fibrosis), head on over to PubMed, and find studies linking it to GUT HYGIENE.  In fact, I just showed you how all diseases are intimately related to each other and are only slightly different variations of the exact metabolic dysfunctions (HERE).  You can also find thousands of studies showing how severely antibiotics affect your natural “hygiene” as well — causing almost every disease you can imagine, including cancer (HERE).


You’ve read this far, what’s the point?  Why does any of this really matter — especially when there is so much debate within the medical research community (sorry, but 99% of the practicing medical community is either purposefully clueless or not interested in rocking the boat they are currently sailing through their career on)?  The point is that you probably need to think about health a bit differently than you have in the past. 

We already know that antibiotics will destroy your health in more ways than you can shake a stick at (Hygiene Hypothesis in action — HERE).  We also know that most drugs, to at least some degree, act like antibiotics (HERE).  The cherry on top is that the absurd number of CHEMICALS (vaccines included — see some of the links in the next paragraph) that we are exposed to daily always have deleterious effects on gut flora and microbiome (HERE); never beneficial.

If you are interested in reading more on this topic, I put several posts together (HERE, HERE, HERE, HERE, and HERE).  If you are chronically ill or dealing with CHRONIC PAIN, you might want to take a look at THIS POST as well.  The super cool thing about my site is that I have nothing up my sleeve and am not trying to sell you anything.  I’m simply trying to help you find the most up-to-date information in the field of natural health — information that will hopefully help you begin the process of transforming your health and your life.  Oh; and if you like what you are seeing, be sure to like, share, or follow us on FACEBOOK.

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